Endocrine Abstracts

Aim: serum cortisol dynamic after transsphenoidal pituitary surgery (TSS) in predicting remission and recurrence of CD.Methods: A cohort of 103 CD patients from a referral center was prospectively analyzed at 111 TSS in 6.0±4.8 years of follow-up. Twenty patients received glucocorticoids in transoperative and had serum cortisol measured at 10–12 days after TSS (Protocol I). Eighty six patients had serum cortisol measured at each 6 h in the firs...

Rationale: In chronic fatigue syndrome (CFS) there is a great controversy about the role of the ACTH/cortisol axis. To examine this phenomena we performed ITT tests in CFS patients with low fasting cortisol (<20 μg/dl). A group of CFS patients with other hypofysal dysfunction were also examined.Methods: One hundred and one patients who underwent classical fasting ITT were registered and analyzed: glucose, cortisol, ACTH and GH were measured and ...

GIP-dependent Cushing’s syndrome (CS) is caused by ectopic expression in adrenal cortex of gastric inhibitory peptide (GIP) receptors coupled to steroidogenesis, which leads to postprandial increases of cortisol (food-dependent CS). In a few cases a transient effect of short-acting octreotide on cortisol levels has been shown, but bilateral adrenalectomy is still thought to be a definitive treatment.We report on a case of a 45-year old woman with bi...

A 38-year-old woman with chronic autoimmune thyroiditis and hypothyroidism treated with levothyroxine (125 μg/day) was referred to our outpatient clinic with a history of sudden increase of goiter, weakness, dysphagia, dyspnea and suffocating sensation. Physical examination showed an enlarged, stony thyroid gland (three times of normal), without palpable cervical lymph nodes. Biochemical evaluation showed the following abnormalities: TSH 6.0 μU/ml (0.4–4.3), fre...

It is becoming increasingly evident that pathways exist within the (ER) that can impact upon cellular redox status, glucocorticoid metabolism and glucose homeostasis.Within the ER of the liver, glucose-6-phosphatase (G6Pase) and glucose 6-phosphate (G6P) transporter (G6PT) work together to increase blood glucose concentrations by performing the terminal step in both glycogenolysis and gluconeogenesis. The G6Pase ‘shares’ G6P with hexose-6-phosp...

Background: Diabetes Mellitus is a chronic metabolic disorder with grievous complications affecting every aspect of patients’ life. Availability of social support helps patients to cope better with the disease, hence positively affecting medication adherence and glycemic control.Objectives: To assess the types of perceived social support and its relationship to medication adherence among T2DM patients attending a public hospital in Lagos, Nigeria.</...

Background: Diabetes Mellitus is a chronic metabolic disorder with grievous complications affecting every aspect of the patients’ life. Availability of social support helps patients to cope better with the disease, hence positively affecting their quality of life.Objectives: To assess the level of perceived social support and its relationship to health-related quality of life of T2DM patients attending a public hospital in Lagos, Nigeria.<p clas...

Introduction: Pseudohypoparathyroidism (PHP) refers to a group of rare sporadic or inherited disorders characterized by parathyroid hormone (PTH) resistance. We report a case of PHP with phenotypical expression and multiple hormonal resistance.Case description: We report a 26-year-old lady who presented to us after a fall, with history of recurrent seizures since 12 years of age. There was a history of oligomennorhoea. Physical examination revealed round...

Background: HbA1c remains the most powerful outcome measure for children and young people with diabetes. It is collected at every clinic visit and is used for individualised discussions around diabetes control and for national benchmarking. However, despite DCCT and IFCC standardisation, there is still no overall consensus as to the most appropriate methodology, particularly when assessing patients with haemoglobinopathies that may affect HbA1c measurement.<p class="abstex...

Introduction: Obesity was thought to be protective against osteoporosis, but studies have shown conflicting results. We analysed the cross-sectional data from the National Health and Nutrition Examination Survey Data (NHANES) survey (2008–2012) to observe the association between BMI (BMI and/or waist circumference) and bone mineral density (BMD) at the femoral neck.Research methods and design: We categorised the study population (women aged 50 years...